Additional file 1 of Analysis of proteome and post-translational modifications of 2-hydroxyisobutyrylation reveals the glycolysis pathway in oral adenoid cystic carcinoma

Additional file 1: Supplementary text. Detailed research methods. Supplementary Fig. 1. PPI and cluster of hyper-modified DHMPs. Supplementary Fig. 2. PPI and cluster of hypo-modified DHMPs. Supplementary Table 1. Statistics of Mass Spectrometry Data. Supplementary Table 2. Clinical characteristics of OACC patients. Supplementary Table 3. Go enrichment analyses of differentially expressed proteins. Supplementary Table 4. KEGG pathway enrichment of differentially expressed proteins. Supplementary Table 5. Go enrichment analyses of differentially expressed and 2-hydroxyisobutyrylated modified proteins. Supplementary Table 6. KEGG pathway enrichment of differentially expressed and 2-hydroxyisobutyrylated modified proteins. Supplementary Table 7. Top 10 hub proteins in hyper-and hypo modified DHMPs based on degree. Supplementary Table 8. KEGG enrichment in up cluster 1–6. Supplementary Table 9. KEGG enrichment in down cluster 1–2. Supplementary Table 10. The Khib of glycolysis pathway enzyme.

补充材料1：补充文本。详细研究方法。补充图1：高修饰DHMPs的蛋白质相互作用（Protein-Protein Interaction，PPI）及聚类分析。补充图2：低修饰DHMPs的蛋白质相互作用（Protein-Protein Interaction，PPI）及聚类分析。补充表1：质谱数据统计。补充表2：OACC患者临床特征。补充表3：差异表达蛋白质的基因本体（Gene Ontology，GO）富集分析。补充表4：差异表达蛋白质的京都基因与基因组百科全书（Kyoto Encyclopedia of Genes and Genomes，KEGG）通路富集分析。补充表5：差异表达且2-羟基异丁酰化修饰蛋白质的基因本体富集分析。补充表6：差异表达且2-羟基异丁酰化修饰蛋白质的京都基因与基因组百科全书通路富集分析。补充表7：基于节点度值的高、低修饰DHMPs前10位核心蛋白质。补充表8：上调聚类簇1~6的京都基因与基因组百科全书富集分析。补充表9：下调聚类簇1~2的京都基因与基因组百科全书富集分析。补充表10：糖酵解通路酶的2-羟基异丁酰化修饰。