Research on the mechanism of the pro-angiogenic effect of naringin in vivo and in vitro based on PIWI-interacting RNA-piRNA Seq

At present, the mechanism about naringin in the process of angiogenesis is not clear. PIWI protein-interacting RNA (piRNA) is a member of small non-coding RNA (sncRNA), which has the functions of regulating protein synthesis, regulating the structure of chromatin and genome, stabilizing mRNA and other functions. Several studies have demonstrated that piRNA can mediate angiogenesis process. And whether naringin can interfere with the process of angiogenesis by regulating piRNA and related target genes deserves further exploration. Thus, the purpose of this study is to validate the potential angiogenic and bone regeneration properties and related mechanisms by naringin both in vivo and in vitro.