Effect of central serous chorioretinopathy patients by covering sick eye for 48 hours

ABSTRACT Purpose: To assess the effect of continuously covering the sick eye affected with central serous chorioretinopathy for 48 h. Methods: This retrospective, case-control study involved 32 central serous chorioretinopathy patients categorized in the treatment group composed of 17 sick eye that received continuous covering treatment for 48 h with a medical gauze and the observation group composed of 15 of these patients who were followed up. None of the patients received any other treatments or medications. The logarithm of the minimal angle of resolution (logMAR) best-corrected visual acuity, macular retinal thickness, and the root mean square value of the amplitude density in the first ring of multifocal electroretinogram were examined before and after the 48-h treatment. Results: After the continuous treatment, the logMAR best-corrected visual acuities were 0.31 ± 0.18 and 0.56 ± 0.37 in the treatment and observation groups, respectively (p=0.019). The macular retinal thicknesses were 461 ± 43 µm and 498 ± 50 µm in the treatment and observation groups, respectively (p=0.032). The root mean square values of the amplitude density in the first ring of multifocal electroretinogram were 32.5 ± 5.3 nV/deg2 and 26.6 ± 4.3 nV/deg2 in the treatment and observation groups, respectively (p=0.002). Conclusions: The continuous application of the covering treatment for 48 h on the sick eye showed positive outcomes with respect to the best-corrected visual acuity, macular retinal thickness, and macular retina functions in the treatment of central serous chorioretinopathy.

摘要
目的：评估连续遮盖中心性浆液性脉络膜视网膜病变（central serous chorioretinopathy）患眼48小时的治疗效果。
方法：本回顾性病例对照研究纳入32例中心性浆液性脉络膜视网膜病变患者，分为治疗组与观察组：治疗组包含17只患眼，采用医用纱布连续遮盖治疗48小时；观察组包含15例患者，仅接受随访。所有患者均未接受其他治疗或药物干预。在48小时治疗前后，检测两组患者的最小分辨角对数（logarithm of the minimal angle of resolution，logMAR）最佳矫正视力、黄斑视网膜厚度，以及多焦视网膜电图（multifocal electroretinogram）第一环振幅密度的均方根值。
结果：治疗后，治疗组与观察组的logMAR最佳矫正视力分别为0.31±0.18和0.56±0.37（p=0.019）；黄斑视网膜厚度分别为461±43 µm和498±50 µm（p=0.032）；多焦视网膜电图第一环振幅密度的均方根值分别为32.5±5.3 nV/deg²和26.6±4.3 nV/deg²（p=0.002）。
结论：对中心性浆液性脉络膜视网膜病变患眼连续实施48小时遮盖治疗，可在最佳矫正视力、黄斑视网膜厚度及黄斑视网膜功能方面获得积极的治疗效果。