Additional file 1 of Sex steroid hormones and risk of breast cancer: a two-sample Mendelian randomization study

Additional file 1. S1. Exposure instruments to proxy hormone levels in the overall breast cancer incidence MR analysis. S2. The strength of the instruments for each hormone including the variance explained and the F statistic. S3. Hormone and breast cancer incidence associations using the alternative MR methods: MR Egger, weighted median, weighted mode and MR-RAPS. S4. MR intercept calculations to identify evidence of pleiotropy. S5. Genetic correlation results between hormones. S6. Exposure instruments to proxy hormone levels in the subtype specific MR analysis. S7. Exposure instruments to proxy hormone levels in the BRCA1 mutated TNBC MR analysis. S8. Power calculations for each hormone and overall and subtype specific BC analysis.

附加文件1：S1. 整体乳腺癌发病孟德尔随机化（Mendelian Randomization, MR）分析中用于代理激素水平的暴露工具变量。S2. 每种激素对应的工具变量强度，包括解释方差与F统计量。S3. 采用替代孟德尔随机化方法（MR Egger、加权中位数法、加权众数法及MR-RAPS）的激素与乳腺癌发病关联分析结果。S4. 用于识别多效性证据的孟德尔随机化截距计算结果。S5. 激素间的遗传相关分析结果。S6. 亚型特异性孟德尔随机化分析中用于代理激素水平的暴露工具变量。S7. BRCA1突变型三阴性乳腺癌（Triple-Negative Breast Cancer, TNBC）孟德尔随机化分析中用于代理激素水平的暴露工具变量。S8. 针对每种激素以及整体和亚型特异性乳腺癌（Breast Cancer, BC）分析的效力计算结果。