Reviewing findings on the polypeptide sequence of the SARS-CoV-2 S-protein to discuss the origins of the virus: Supplementary figure.pdf

Partial
alignment among genomes of the coronaviruses RaTG13 and SARS-CoV-2 (accession
numbers are available in Table 1) and the nucleotide sequence of BtCoV/4991
(Genbank KP876546.1) [21]. The polypeptide sequence is reported under the
nucleotide sequences. Alignment of the nucleotide sequences is shown until
the end of motif C [24] (red). Cyan, polymorphisms between BtCoV/4991 and
SARS-CoV-2; bold: codon responsible of the amino acid substitution H-to-Y
occurring between RaTG13 and SARS-CoV-2 (in cyan); green: interacting
residues of the palm domain according with Gao et al. [24].

本数据集包含冠状病毒RaTG13、严重急性呼吸综合征冠状病毒2型（SARS-CoV-2，登录号（accession numbers）见表1）以及BtCoV/4991的核苷酸序列（基因银行（GenBank）登录号KP876546.1）[21]的部分基因组序列比对结果。多肽序列附于核苷酸序列下方进行展示。核苷酸序列比对结果展示至基序（motif）C的末端，该基序以红色标注[24]。青色代表BtCoV/4991与SARS-CoV-2之间的多态性位点；加粗字体标注了RaTG13与SARS-CoV-2之间发生H→Y氨基酸替换（amino acid substitution）所对应的密码子（codon），该位点已以青色标注；绿色标注依据Gao等[24]的研究结果确定的棕榈结构域（palm domain）相互作用残基。