Supplementary Material for: Brain-only metastasis and 10-year survival after curative gastric cancer resection: a case report

Gastric cancer (GC) usually metastasizes to locoregional lymph nodes, the peritoneum causing ascites, or to the liver and lungs, but rarely to the brain. Few cases of brain-only GC metastases have been reported, and the prognosis is very poor. We present a case of brain-only metastasis 2 years after curative GC surgery and chemotherapy, who visited the ER due to a headache. The patient underwent operative tumor resection of the brain with additional chemotherapy and is still alive and disease free 10-years after initial curative treatment. This case shows that as brain-only metastasis may have a better prognosis than that of systemic metastasis, aggressive treatment with radiotherapy or surgery with chemotherapy may be needed.

胃癌（GC）通常会转移至区域淋巴结、腹膜（可引发腹水）或肝、肺，但极少转移至脑部。目前仅报道过少数仅发生脑部转移的胃癌病例，且此类病例的预后极差。本次研究报道1例仅发生脑部转移的胃癌病例：患者在接受根治性胃癌手术与化疗2年后，因头痛前往急诊就诊。患者接受了脑部肿瘤切除术联合后续化疗，在初始根治性治疗10年后仍存活且无疾病复发迹象。本病例提示，相较于全身性转移病例，仅发生脑部转移的胃癌患者或许拥有更佳预后，因此或许需要采用放疗或手术联合化疗的积极治疗方案。