CircTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene Tulp4. CircTulp4 functions in Alzheimer’s disease pathogenesis by regulating its parental gene Tulp4

Here, we systematically investigated circRNAs in the APP/PS1 model mouse brain through deep RNA-sequencing. We report that circRNAs are markedly enriched in the brain and that several circRNAs exhibit differential expression between wild-type and APP/PS1 mice. We characterized one abundant circRNA, circTulp4, derived from Intron1 of the gene Tulp4. To investigate the effect of CircTulp4 on chromatin status, we used ATAC-seq to investigate the chromatin accessibility upon CircTulp4 knockdown.