Supplementary Material for: Real-world patient outcomes on the efficacy of lanreotide treatment for neuroendocrine tumors: the influence of BMI, BSA and renal function

Background: Lanreotide is an effective and safe first-line therapy to treat patients with a gastro enteropancreatic (GEP) neuroendocrine tumor (NET). Precision oncology may be used to provide each patient with the right dosage. Pharmacokinetic data suggest lower exposure in higher weight patients. However, no recommendations for dose individualization in specific patient groups exist. Therefore, we aimed to investigate the association of Body Mass Index (BMI), Body Surface Area (BSA), and renal function on the efficacy and toxicity of lanreotide treatment for neuroendocrine tumors. Methods: GEP-NET patients on lanreotide treatment at Amsterdam UMC from 2016-2022 were included. Outcome measures were primarily PFS and secondarily OS and toxicity. Kaplan Meier analyses and Cox’s proportional hazard models were used to calculate median PFS/OS and compare subgroups based on BMI, BSA, and renal function. Results: A total of 122 patients with NETs of diverse origin, functionality and grade were included with a median PFS of 28 months (95%CI, 19.3-36.7). The median OS was not reached. No statistically significant difference in PFS among BMI subgroups was observed although obese patients had the longest PFS (52 months, 95%CI, 27.4-76.7) compared to other BMI categories. No relation between BSA/renal function and PFS or toxicity was found. Conclusion: This large real world data cohort of NET patients treated with lanreotide found no association of BMI, BSA or renal function with PFS. Dose individualization of lanreotide treatment based on the patient characteristics BMI, BSA or renal function does not seem rational based on these findings.