Additional file 1 of Plasma metabolic profiles predict future dementia and dementia subtypes: a prospective analysis of 274,160 participants

Additional file 1: Table S1. UKB Nightingale metabolite measurements and clinical parameters information. Table S2. Detailed dementia outcome definition. Table S3. All 249 metabolites baseline characters of the study participants by dementia case-control status. Table S4. Comparison of covariate distributions for 10 regions. Table S5. Results of associations between plasma metabolites and incident dementia. Table S6. Results of associations between plasma metabolites and incident dementia stratified by sex. Table S7. Results of associations between plasma metabolites and incident dementia stratified by age. Table S8. Results of associations between plasma metabolites and incident dementia stratified by APOE4 carrier status. Table S9. Results of metabolites importance ranking. Table S10. The hazard ratios of MetRS in the full cohort and subgroups. Table S11. Discriminative performance of CPH models.

附加文件1：表S1：英国生物银行（UKB）奈廷格尔血浆代谢物检测指标与临床参数信息。表S2：详细的痴呆结局定义。表S3：本研究参与者按痴呆病例-对照状态划分的全部249种代谢物基线特征。表S4：10个区域的协变量分布对比。表S5：血浆代谢物与新发痴呆的关联分析结果。表S6：按性别分层的血浆代谢物与新发痴呆关联分析结果。表S7：按年龄分层的血浆代谢物与新发痴呆关联分析结果。表S8：按载脂蛋白E4（APOE4）携带状态分层的血浆代谢物与新发痴呆关联分析结果。表S9：代谢物重要性排序结果。表S10：全队列及各亚组中代谢物风险评分（MetRS）的风险比。表S11：Cox比例风险（CPH）模型的判别性能。