Sphaerococcus coronopifolius transcriptomic effect on a canine mastocytoma cell line (C2)

The present study aims to investigate the possible anticancer activity of Sphaerococcus coronopifolius (SC) extract which showed higher cytotoxic effects against a canine mastocytoma cell line (C2) compared to other algal extracts screened. A whole-transcriptomic approach was applied to understand transcriptional changes and pathways modulated by SC. Such findings will contribute to enhancing our understanding of the mechanisms involved in the anticancer activity of this extract and highlighting possible hopes and challenges to be faced in the use of natural compounds.