Synthesis and Characterization of a Chromium(V) cis-1,2-Cyclohexanediolato Complex: A Model of Reactive Intermediates in Chromium-Induced Cancers

Stabilization of chromium­(V) by biological 1,2-diolato ligands, e.g., carbohydrates and glycoproteins, is postulated to be crucial for both the chromium­(VI)-induced carcinogenicity and chromium­(III) antidiabetic activities. Close structural mimics of biologically relevant chromium­(V) 1,2-diolato complexes, M­[CrVO­(chd)2] [chd = cis-1,2-cyclohexanediolato­(2−)], were synthesized and characterized by X-ray crystallography (M = Na) or by spectroscopic techniques, including X-ray absorption spectroscopy (M = K). This is the first structurally characterized chromium­(V) complex with a cyclic diolato ligand.