The investigation of airway management capacity of v-gel and cobra-PLA in anaesthetised rabbits

PURPOSE:To evaluate the applicability and airway management capacity of v-gel(r) and Cobra PLA in rabbit anaesthesia during assisted (AV) or controlled ventilation (CV).METHODS:This study was carried out in 44 adult New Zealand white rabbit. Baseline arterial pH, PaCO2 and PaO2 values were recorded. Anaesthesia was induced with 5 mg/kg xylasine and 35 mg/kg ketamine HCI combination. AV rabbits were assigned as; control (CG-AV; n=5), LMA (LMA-AV; n=5), cobra PLA (PLA-AV; n=5) and v-gel (v-gelAV; n=5). Rabbits have CV were also assigned as; ET (ET-CV; n=6), LMA (LMA-CV; n=6), cobraPLA (PLA-CV; n=6) and v-gel (v-gelCV; n=6). All measurements were repeated 1st, 5th, 15th and 30th mins during anaesthesia.RESULTS: The less insertion time, number of attempt and complications are recorded in v-gel applied rabbits compared to other apparatus. For arterial pH values significant differences are recorded in especially at 15th and 30th min between groups of CV (p<0.005 or p<0.001). All groups had similar results with each other during anaesthesia for PaCO2 except for LMA-CV group.CONCLUSION:The v-gel may be used as airway device in rabbit anaesthesia undergoing AV or CV and also can be a suitable alternative to endotracheal tubes and laryngeal mask airway.

研究目的：评估v-gel（v-gel(r)）与Cobra PLA（Cobra PLA）在辅助通气（assisted ventilation, AV）或控制通气（controlled ventilation, CV）下的兔麻醉气道管理适用性与能力。
研究方法：本研究共纳入44只成年新西兰白兔。记录基线动脉pH值、动脉血二氧化碳分压（PaCO2）与动脉血氧分压（PaO2）。采用5 mg/kg赛拉嗪与35 mg/kg盐酸氯胺酮（ketamine HCI）复合方案诱导麻醉。将接受辅助通气（AV）的白兔分为4组：对照组（CG-AV；n=5）、喉罩通气道组（LMA-AV；n=5）、Cobra PLA组（PLA-AV；n=5）与v-gel组（v-gelAV；n=5）。将接受控制通气（CV）的白兔亦分为4组：气管导管组（ET-CV；n=6）、喉罩通气道组（LMA-CV；n=6）、Cobra PLA组（PLA-CV；n=6）与v-gel组（v-gelCV；n=6）。于麻醉期间的第1、5、15及30分钟重复采集所有测量指标。
研究结果：相较于其他气道装置，使用v-gel的白兔气道装置置入时间更短、置入尝试次数更少且相关并发症发生率更低。在控制通气组中，各组动脉pH值尤其在第15、30分钟时存在显著差异（p<0.005 或 p<0.001）。除LMA-CV组外，其余各组在麻醉期间的PaCO2水平均无显著组间差异。
结论：v-gel可作为接受辅助通气或控制通气的兔麻醉气道管理装置，同时可作为气管导管与喉罩通气道的合适替代方案。