Background: Periods of inactivity experienced by older adults induce nutrient anabolic resistance creating a cascade of skeletal muscle transcriptional and translational aberrations contributing to mu
Cells were amino acid refed at High AA concentrations (9 mM) with or without presence of inhibitors of molecules in the IGF-1receptor signaling pathway (mean±SE, n = 4-5/group).
Exercise is a behavior modification?indispensable for long-term weight loss. Exercise activates the Creb-Regulated Transcriptional Coactivator (Crtc) family of transcriptional coregulators to drive Cr
We address whether the functions of HDAC3 in skeletal muscle require its enzyme activity. By mutating the NCoR/SMRT corepressors in a knock-in mouse model named NS-DADm, we ablated the enzymatic activ
