Copper-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Imino Esters to Unsaturated Sultones
收藏NIAID Data Ecosystem2026-03-11 收录
下载链接：
https://figshare.com/articles/dataset/Copper-Catalyzed_Asymmetric_1_3-Dipolar_Cycloaddition_of_Imino_Esters_to_Unsaturated_Sultones/12449156
下载链接
链接失效反馈官方服务：
资源简介：
The
asymmetric 1,3-dipolar cycloaddition of glycine imino esters
to 1-propene-1,3-sultone or sulfocoumarins is described. The reaction
was efficiently catalyzed by Cu(MeCN)4BF4/DTBM-Segphos
or Cu(MeCN)4BF4/tBu-FcPhox
at room temperature to afford fused pyrrolidines as single regioisomers
with excellent diastereoselectivity and enantioselectivity. The broad
substrate scope of this reaction provides convenient access to structurally
diverse multisubstituted pyrrolidines in an optically pure fashion.
创建时间：
2020-05-29
