MACE sequencing of the choroid plexus of S. suis infected pigs with meningitis or meningitis-free

The zoonotic pathogen, Streptococcus suis, has been demonstrated to use the choroid plexus as an entry gate into the central nervous system, where it can induce meningitis. The global transcriptome of primary porine and immortal human choroid plexus epithelial cells, which were infected in vitro with S. suis, was analyzed via RNA-seq. Additionally, the choroid plexus was isolated from pigs experimentally infected in vivo with S. suis and who either suffered from meningitis or were meningitis-free. These tissue samples were also subject of global transcriptomee analysis via conventional RNA-seq and sequencing via Massive Analysis of cDNA Ends (MACE).