An essential role for MEF2C in the cortical response to loss of sleep

Insight on molecular and cellular responses to sleep loss provides a clearer understanding of sleep function. Neurobiological changes in the mouse frontal cortex in response to sleep loss, involving transcriptomic architecture, regulation of synaptic strength in excitatory cortical neurons and SWS-SWA, correlated with sleep need.对睡眠剥夺引发的分子与细胞应答的深入解析，可为阐明睡眠的生物学功能提供更清晰的视角。睡眠剥夺下小鼠前额叶皮层的神经生物学变化涉及转录组架构（transcriptomic architecture）、兴奋性皮层神经元（excitatory cortical neurons）的突触强度调控以及慢波睡眠-慢波活动（Slow Wave Sleep-Slow Wave Activity，SWS-SWA），上述变化与睡眠需求相关联。