Case-only meta-analysis of cohort Ia and cohort IIb in a total of 712 SLE cases.

a Uppsala, Stockholm, Lund, n = 567 cases.b Linköping, n = 145 cases.c WHO class III or IV on renal biopsy, according to the 1995 WHO classification system [2].d Glomerular filtration rate 2[22].e Unadjusted p-value and OR for difference in allele frequencies between patients with (n = 230) and without (n = 482) lupus nephritis.f Unadjusted p-value and OR for difference in allele frequencies between patients with proliferative nephritis (n = 112) and SLE without proliferative nephritis (n = 548; SLE without LN, n = 482 and LN other than proliferative, n = 66).g Unadjusted p-value and OR for difference in allele frequencies between patients with severe renal insufficiency (n = 31) and SLE without severe renal insufficiency (n = 676; SLE without LN, n = 482 and LN without severe renal insufficiency at follow-up, n = 194). P-value remaining significant after Bonferroni correction for 4 tested SNPs is in italic.h Adjusted p-value and OR from meta-analysis of logistic regression results including disease duration and gender as covariates. Number of cases in each analysis; LN/non-LN: 225/481, proliferative nephritis/non-proliferative nephritis: 109/545, severe renal insufficiency/non-severe renal insufficiency: 31/670.