Plasma untargeted metabolomics data of male and female rats under 8:2 FTOH exposure

We previously found that 8:2 FTOH overactivates AHR and results in abnormal mitochondrial metabolism. To study the role of AHR overactivation <i>in vivo</i>, male and female Wistar rats were administered different concentrations of 8:2 FTOH by gavage for 28 days. At the end of the treatment, plasma was collected for broadly targeted metabolomics and lipid metabolomics analysis.

本团队前期研究发现，8:2 FTOH可过度激活芳香烃受体（Aryl Hydrocarbon Receptor, AHR），并引发线粒体代谢异常。为探究AHR过度激活的体内（in vivo）生物学作用，本实验通过灌胃方式向雄性和雌性Wistar大鼠给予不同浓度的8:2 FTOH，持续染毒28天。染毒结束后采集血浆，进行广靶代谢组学与脂质代谢组学分析。