Tumor response and biomarkers for Top1 inhibitors in topotecan-nonresponsive and moderately responsive xenograft models.

Abbreviations: C, control group; d, day; IP, intraperitoneal; IV, intravenous; NA, not applicable; ND, not determined QD×5, treated for 5 sequential days at designated dose; T, treated group.a. No mice were tumor-free by study day 70.b. A death is considered treatment-related if the animal dies within 15 days of the last treatment and either the tumor weight is less than the lethal burden in the control mice or its net body weight loss at death is 20% greater than the mean net weight change in the control animals at death or sacrifice.