Statistically significant pairwise correlations among the factors in the top 200 orthobiologics combinations as determined from the neural network.

BMP2 and BMP7 are positively correlated, while OG and PDGF are negatively correlated. PDGF is negatively or positively correlated with BMAC or PRP, respectively. PU and ES are negatively correlated, and BMAC and PRP are also negatively correlated. The very low (but still > 0) p values associated with those last two negative correlations is attributed mainly to constraints in the design of the combination screen by which PU and ES could not be nonzero together, and BMAC and PRP likewise could not be nonzero together. All values including p values are reported to four significant places.