Supporting data for: Three-dimensional genome re-wiring in loci with Human Accelerated Regions
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https://datadryad.org/dataset/doi:10.7272/Q6057D5N
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资源简介：
Human Accelerated Regions (HARs) are conserved genomic loci that evolved
at an accelerated rate in the human lineage and may underlie
human-specific traits. We generated HARs and chimpanzee accelerated
regions with an automated pipeline and an alignment of 241 mammalian
genomes. Combining deep-learning with chromatin capture experiments in
human and chimpanzee neural progenitor cells, we discovered a significant
enrichment of HARs in topologically associating domains (TADs) containing
human-specific genomic variants that change three-dimensional (3D) genome
organization. Differential gene expression between humans and chimpanzees
at these loci suggests rewiring of regulatory interactions between HARs
and neurodevelopmental genes. Thus, comparative genomics together with
models of 3D genome folding revealed enhancer hijacking as an explanation
for the rapid evolution of HARs.
提供机构：
Dryad
创建时间：
2023-02-01
