small molecule inhibitor in complex with PD-L1

small molecule inhibitor in complex with PD-L1 Descriptor: Programmed cell death 1 ligand 1, ~{N}-[2-chloranyl-3-[2-chloranyl-3-[4-[[[2-(hydroxymethyl)-1,3-bis(oxidanyl)propan-2-yl]amino]methyl]-3-methoxy-phenyl]phenyl]phenyl]-5-[[[2-(hydroxymethyl)-1,3-bis(oxidanyl)propan-2-yl]amino]methyl]pyridine-2-carboxamide Authors: Muszak, D, Kocik-Krol, J, Zaber, J, Kruc, O, Palej, U, Fijolkowska, K, Maslanka, A, Magiera-Mularz, K, Plewka, J, Stec, M, Siedlar, M, Musielak, B, Kitel, R, Skalniak, L, Surmiak, E. Deposit date: 2025-04-05 Release date: 2026-02-18 Last modified: 2026-02-25 Method: X-RAY DIFFRACTION (1.75 Å) Cite: N-terphenylpicolinamide derivatives designed to target PD-L1 increase activation and proliferation of T cells, and their cytotoxic properties toward cancer cells. Eur.J.Med.Chem., 307, 2026