Transcriptome analyses of cerebral ischemia reveal functional lncRNAs in ischemia stroke

Conclusions: This study reports the genome-wide lncRNA profiles in ischemia stroke using high throughput sequencing and constructs a systematic lncRNA-miRNA-mRNA network which reveals a complex functional noncoding RNA regulatory network in ischemia stroke.研究结论：本研究采用高通量测序技术，解析了缺血性脑卒中的全基因组长链非编码RNA（long non-coding RNA, lncRNA）表达谱，并构建了系统性的lncRNA-微小RNA（microRNA, miRNA）-信使RNA（messenger RNA, mRNA）调控网络，该网络揭示了缺血性脑卒中中复杂的功能性非编码RNA调控网络。