Recruitment of Brca1 to Unsynapsed Regions

Unsynapsed regions of chromosomes are silenced during pachytene by a process called Meiotic Silencing of Unsynapsed Chromatin (MSUC) and, in the case of the X and Y chromosomes, Meiotic Sex Chromosome Inactivation (MSCI). Unsynapsed meiotic chromatin recruits Brca11 (Turner et al. 2004, Turner et al. 2005, Mahadevaiah et al. 2008, Kouznetsova et al. 2009). The recruitment requires Sycp3 of axial elements of the synaptonemal complex, which may remain exposed in unsynapsed regions (Kouznetsova et al. 2009).

染色体在减数分裂过程中，通过称为减数染色质非联合沉默（Meiotic Silencing of Unsynapsed Chromatin, 简称MSUC）的机制，使得非联合区域（Unsynapsed regions）失活，尤其在X和Y染色体的情形下，这一过程被称为减数性别染色体失活（Meiotic Sex Chromosome Inactivation, 简称MSCI）。非联合的减数期染色质会招募Brca11蛋白（Turner et al. 2004, Turner et al. 2005, Mahadevaiah et al. 2008, Kouznetsova et al. 2009）。此招募过程依赖于联会复合体轴心元件的Sycp3蛋白，该蛋白可能在非联合区域中保持暴露状态（Kouznetsova et al. 2009）。