Comparison of Genetic and Epigenetic Profiles of Periodontitis According to the Presence of Type 2 Diabetes

Type 2 diabetes mellitus (T2DM) and periodontitis (PD) have intricate connections as chronic inflammatory diseases. While the immune response is a key factor that accounts for their association, the underlying mechanisms remain unclear. To gain a deeper understanding of the connection, we conducted research using a multi-omics approach. We generated whole genome and EPIC array data from periodontium of PD patients with DM (PDDM) and without DM to confirm genetic and epigenetic changes. Independent bulk and single-cell RNA sequencing data were employed to verify the expression levels of hypo-methylated genes. Here, we supply whole genome sequencing data.