Relationship between periodontal outcomes and serum biomarkers changes after non-surgical periodontal therapy

Abstract: The systemic effect of chronic periodontitis (CP) has been suggested by several studies as an etiologic factor and modulator of diseases based on the changes in the inflammatory marker levels. This study aimed to investigate the relationship between the changes in clinical periodontal outcomes and serum biomarkers (CRP, IL-6, albumin and percentage of leukocytes) after non-surgical periodontal therapy in systemically healthy adults. An interventional study was conducted with a sample of 29 individuals without CP (control group) and 33 with CP (CP group). Periodontal clinical variables were recorded, and the serum levels of inflammatory markers were measured. Statistical analysis included the chi-square and Student’s t-tests and Pearson’s correlation analysis. After 90 days of non-surgical periodontal treatment, a reduction of periodontal parameters and IL-6 in both groups could be observed (P < 0.001). The correlation analysis revealed a directly proportional correlation between changes in the probing depth (r = 0.349, P = 0.049) and clinical attachment level (r = 0.374, P = 0.034) with CRP in the CP group. The findings suggest a reduction of IL-6 serum concentration and periodontal clinical measures 90 days after periodontal therapy in both groups.

摘要：多项研究已证实，慢性牙周炎（chronic periodontitis，CP）可通过改变炎症标志物水平，成为多种疾病的病因相关因素及调节因子，其全身效应逐渐受到关注。本研究旨在探讨全身健康成人接受非手术牙周治疗后，临床牙周结局变化与血清生物标志物（C反应蛋白（C-reactive protein，CRP）、白细胞介素-6（Interleukin-6，IL-6）、白蛋白及白细胞百分比）之间的关联。本研究为干预性研究，共纳入29名无慢性牙周炎者作为对照组，33名慢性牙周炎患者作为CP组。研究人员记录了所有受试者的牙周临床变量，并检测其血清炎症标志物水平。统计学分析采用卡方检验、Student t检验及Pearson相关分析。经90天非手术牙周治疗后，两组的牙周参数及IL-6水平均显著降低（P < 0.001）。相关分析结果显示，在CP组中，探诊深度变化（r=0.349，P=0.049）与临床附着水平变化（r=0.374，P=0.034）均与CRP水平呈正相关。本研究结果表明，两组受试者在牙周治疗90天后，血清IL-6浓度及牙周临床指标均得到显著改善。