The MAPP II Study of Urologic Chronic Pelvic Pain Syndrome: The Trans-MAPP Symptom Patterns Study

The second phase (MAPP II) of the NIDDK Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network was designed to conduct a prospective, observational study of men and women with urologic chronic pelvic pain syndrome (UCPPS). The MAPP II central protocol, the Trans-MAPP Symptom Patterns Study (SPS), phenotypically characterized UCPPS participants (and a limited number of healthy control participants) during an initial run-in period, at baseline, and during an extended follow-up period (up to 36 months) to further identify clinical and biologic factors associated with worsening and/or improvement of reported urinary and non-urinary symptoms and to further define clinically relevant UCPPS phenotypic subgroups. A central goal of MAPP II, like MAPP I, was to create a new knowledge base for informing future, targeted UCPPS clinical trials and ultimately to provide insights that will improve the clinical management of patients.

Participants completed a series of in-clinic study visits at various time points, as well as online internet-based questionnaires in clinic and off site/at home, in which diverse patient-reported data was collected assessing urologic and non-urologic symptoms, health care utilization, flare status, and quality of life, among other domains. Physical exams and pelvic exams were also conducted at in-clinic visits. Biological samples were collected at various timepoints to allow studies of biomarkers, immunologic contributors, and the urologic microbiome. The study also applied promising research methods in the pain field (e.g., functional/structural neuroimaging, quantitative sensory testing, and newly derived body pain maps) at baseline and longitudinally to allow for further systemic characterization of UCPPS in men and women.

MRI images for MAPP II participants are not included in the package, but are available upon request