Polygonatum sibiricum Polysaccharide Modulates Gut Microbiota and Bile Acid Homeostasis to Ameliorate Colitis
收藏国家人口健康科学数据中心2026-06-06 收录
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https://www.ncmi.cn/phda/dataDetails.do?id=CSTR:17970.11.A001G.202601.124.V1.0
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资源简介：
Inflammatory bowel disease (IBD) relates to gut microbiota dysbiosis, bile acid (BA) disturbance and intestinal barrier impairment. We purified a fructose-dominant (Fru 93.63%) low-molecular-weight Polygonatum sibiricum polysaccharide (PSP). In 3% DSS-induced colitis in C57BL/6 mice, PSP (400 mg/kg/day) alleviated symptoms. Multi-omics showed PSP reversed DSS-induced disorders, regulated BA biosynthesis, restored barrier function and mitigated colitis, supporting its IBD intervention potential.
提供机构：
北京蛋白质组研究中心创建时间：
2026-01-26
