Raw data for the association of genetic variants of ErbB4 gene and gestational diabetes mellitus

Gestational diabetes (GDM) is one of the common complications of female pregnancy, which seriously affects the health of patients and their offspring. So far, the etiology has not yet been fully clarified. To clarify the relationship of Erb-b2 receptor tyrosine kinase 4 (ErbB4) genetic variants and GDM risk in a Chinese population, ErbB4 variants (rs1595064, rs1595065, rs1595066 and rs6719645) were selected and genotyped in 554 GDM cases and 641 healthy controls. The associations between variants and GDM risk were evaluated with the odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). The false-positive reporting probability (FPRP), multi-factor dimension reduction (MDR) and bioinformatics analysis were adopted to confirm the significant associations. A nomogram model was constructed to predict the risk of GDM. Association analysis demonstrated that the rs1595066 genotype performed a protective effect on GDM risk among whole subjects. Meanwhile, stratified analysis ...

妊娠糖尿病（GDM）是女性妊娠期常见并发症之一，严重威胁母婴健康。截至目前，其病因尚未完全阐明。为明确中国人群中Erb-b2受体酪氨酸激酶4（ErbB4）基因变异与GDM发病风险的关联，本研究选取rs1595064、rs1595065、rs1595066及rs6719645共4个ErbB4基因变异位点，对554例GDM病例及641例健康对照进行基因分型。通过比值比（OR）及其对应95%置信区间（CI）评估各变异位点与GDM发病风险的关联；采用假阳性报告概率（FPRP）、多因子降维法（MDR）及生物信息学分析验证所得关联的显著性。此外，本研究构建列线图模型以预测GDM发病风险。关联分析结果显示，在全体研究对象中，rs1595066基因型对GDM发病风险具有保护作用；与此同时，分层分析……