遇见数据集

Per-sample data for: Transferability of Published qNet Risk Thresholds Across Sex and Heart Failure in Ventricular Substrates

收藏
Zenodo2026-08-19 更新2026-08-20 收录
官方服务:

资源简介:

Simulation output underlying every figure and table of the associated manuscript. Single-cell O'Hara-Rudy simulations using the CiPA-optimised variant of Dutta et al.2017, paced at a basic cycle length of 2,000 ms (0.5 Hz) for 1,000 beats, withbiomarkers taken from the final beat. Twelve ventricular substrates are formed fromfour sex-by-disease phenotypes (healthy and heart failure, in both sexes) crossed withthree transmural layers (endocardium, epicardium, mid-myocardium). Drug potency wasresampled 2,000 times per condition by parametric bootstrap over the IC50 values ofKramer et al. 2013. Contents (109 files):- per_sample/ 72 files, one per layer / drug / concentration / phenotype, 2,000 rows each, one row per uncertainty-quantification sample- baselines/ 3 files, the twelve drug-free substrates, one row per phenotype- traces/ 12 files, full current traces for the drug-free substrates, one complete 2,000 ms cycle- summaries/ 18 files, per-condition minimum, maximum and median with the change from the matching drug-free baseline- thresholds.csv the published per-cell-type qNet decision thresholds applied- reproduce.py standard-library script that recomputes the manuscript's headline results from the files above- README.md full column definitions and usage cautions- LICENSE.txt CC BY 4.0 Every label is carried in a filename or a column, never by row or directory position.Concentrations in path names are nanomolar. Files are restricted pending publication of the associated manuscript.

提供机构:
Zenodo
创建时间:
2026-08-18
二维码
社区交流群
二维码
科研交流群
商业服务