AGODB

Argonaute (Ago) proteins are widely expressed in almost all organisms. Eukaryotic Ago (eAgo) proteins play a critical role in the biogenesis of small RNAs and prokaryotic Ago (pAgo) proteins defend against invading nucleic acids via binding small RNA or DNA. Protein domains are fundamental units of protein structure, function, and evolution, whereas the domains of Ago proteins are not well annotated/curated currently. Therefore, a comprehensive domain annotation database of Ago proteins is lacking, and it is not conducive for researchers to understand the function and mechanism of argonaute proteins. Herein, we constructed the first online resource (AGODB), a comprehensive domain annotation database of Ago proteins. AGODB curates domain annotation, specially for long pAgos, all six domains are annotated/curated. The database also allows users to search the database with a variety of options and download the search results.