Analysis of the intestinal and oropharyngeal microbiome, nutritional and immunological profile of children with Autism Spectrum Disorder (ASD) compared with children without

The present work proposes an innovative approach because in previous studies it has been the intestinal microbiota has been prioritized and the role of the microbiota of the Oropharynx in autism spectrum disorders, despite having reports from the connection between changes in the intestinal and oropharyngeal microbiota. The results of this analysis has the potential to give rise to relevant information for theinvestigation of the interconnections that influence the ASD. Changes that are evidenced in the composition and physiology of the oropharyngeal and intestinal microbiome compare the cases of ASD and controls, will allow to delimit the mechanisms metabolic, neurological and immunological that mediate and underlie the symptomatology of the ASD. Therefore, this research will focus on the study of the microbiota Oropharyngeal along with the intestinal to correlate the epidemiological data of thechildren with ASD, contrasting with the control children. The information compiled will incorporate new evidence into the scheme followed by the effector mechanisms of the neurological alterations of ASD. In this study we will investigate the diversity, composition and richness patterns of the microbiota of children with and without ASD. The data will allow us to find associations between ASD disorders with comorbidities such as gastric problems, respiratory and immunological. We will compare the information provided by parents about dietary factors, medication consumption, nutritional behaviors, other chronic diseases, care of the mother during pregnancy and other factors that can be correlated with the patterns of the microbiota found.With these data you can identify what types of bacteria are associated with the states healthy and with the decrease of the severity of the symptoms of ASD.