GBAP1 polymorphisms (rs140081212, rs1057941 and rs2990220) contribute to the reduced risk of gastric cancer
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<strong><em>Propose:</em></strong> The purpose of this study is to evaluate the contribution of <em>GBAP1</em> genetic variants to the risk of gastric cancer (GC) occurrence among a Chinese Han population. <strong><em>Methods:</em></strong> This study included 509 GC patients and 507 healthy controls. The genotypes of <em>GBAP1</em> polymorphisms were detected by Agena MassARRAY platform. Logistic regression analysis was used for the association between <em>GBAP1</em> polymorphisms and GC predisposition by calculating Odds ratio (OR) and 95% confidence interval (CI) adjusted for age and gender. <strong><em>Results: </em></strong><em>GBAP1</em> rs140081212 (OR = 0.51, <em>p</em> = 4.50´10<sup>-07</sup>), rs1057941 (OR = 0.48, <em>p</em> = 1.19´10<sup>-08</sup>) and rs2990220 (OR = 0.46, <em>p</em> = 7.34´10<sup>-09</sup>) contribute to the reduced risk of GC incidence. Interestingly, the contribution of <em>GBAP1</em> genetic variants to GC susceptibility was associated with age, gender, BMI and the status of smoking and drinking. Besides, rs140081212 (OR = 0.47, <em>p</em> = 1.70´10<sup>-06</sup>), rs1057941 (OR = 0.43, <em>p</em> = 4.43´10<sup>-08</sup>) and rs2990220 (OR = 0.43, <em>p</em> = 2.66´10<sup>-07</sup>) variants had the relationship to the decreasing risk of gastric adenocarcinoma. <strong><em>Conclusion: </em></strong>Our research suggested that <em>GBAP1</em> polymorphisms (rs140081212, rs1057941 and rs2990220) might provide a protective effect on GC occurrence among a Chinese Han population. Our finding might increase the understanding of molecular genetics in gastric carcinogenesis.
