It is now widely known that C-X3-C motif ligand 1 (CX3CL1) plays an essential part in the process of regulating pro-inflammatory cells migration across a wide range of inflammatory disorders, includin

NIAID Data Ecosystem00

Table 1_PIK3CA mutation–induced immune microenvironment remodeling sensitizes cervical cancer to immunotherapy.xlsx

肿瘤免疫治疗

PIK3CA突变生物标志物

PIK3CA is one of the most frequently mutated genes in cervical cancer (CC). However, its clinical utility is hampered by paradoxical treatment-dependent outcomes, restricting its application in precis

NIAID Data Ecosystem00

Transcriptional profile of IL33 & PD1-treated ILC2 from KPC tumor-bearing mice

肿瘤免疫治疗

ILC2细胞转录组

We investigated the genetic profiles of IL33 and PD1-treated group 2 innate lymphoid cells (ILC2) harvested from KPC tumors and draining lymph nodes in a pancreatic ductal adenocarcinoma (PDAC) mouse

NIAID Data Ecosystem10

Unleashing natural IL-18 activity using an anti-IL-18BP blocker antibody induces potent immune stimulation and anti-tumor effects

肿瘤免疫治疗

单细胞转录组学

Recombinant cytokines have limited anti-cancer efficacy mostly due to narrow therapeutic window and systemic adverse effects. IL-18 is an inflammasome induced proinflammatory cytokine that enhances T

NIAID Data Ecosystem00