Heme/Copper Assembly Mediated Nitrite and Nitric Oxide Interconversion
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https://figshare.com/articles/dataset/Heme_Copper_Assembly_Mediated_Nitrite_and_Nitric_Oxide_Interconversion/2466928
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资源简介:
The hemea3/CuB active site
of cytochrome c oxidase is responsible for cellular
nitrite reduction to nitric oxide; the same center can return NO to
the nitrite pool via oxidative chemistry. Here, we show that a partially
reduced heme/Cu assembly reduces NO2– ion, producing nitric oxide. The heme serves as the reductant, but
the CuII ion is also required. In turn, a μ-oxo heme-FeIII–O–CuII complex facilitates NO
oxidation to nitrite; the final products are the reduced heme and
CuII–nitrito complexes.
创建时间:
2016-02-20



