Dataset of Spirocyclic Amide Acetal Synthesis by [CpRu]-Catalyzed Condensations of α‑Diazo-β-Ketoesters with γ-Lactams

The synthesis of spirocyclic amide acetals (33-93%) has been achieved through Ru(II)-catalyzed condensations of N-carbamate protected pyrrolidinones with metal carbenes derived from α‑diazo-β-ketoesters. Thanks to the mildness of the diazo decomposition conditions induced by a 1:1 combination of [CpRu(MeCN)3][BArF] and 1,10-phenanthroline, the formation of the sensitive products is possible. Full characterization of this carbonyl-ylide mediated process is provided by DFT calculations.