Influence of Environmental Co-Infections on Pediatric Infectious Disease Treatment Efficacy: Shotgun Sequencing Insights

123 hospitalized children aged 0-14 years who were admitted to the pediatric department of Xiamen First Hospital with severe infections who were tested for metagenomics next-generation sequencing from 2020 to 2022 were recruited. The Medical Ethics Committee of Xiamen University approved the study, including all procedures (recruitment of participants and all experimental protocols). Written informed consent was obtained from patients selected from Xiamen First Hospital. A total of 123 patients with severe infections were diagnosed by pathological examination. All participants were Chinese residents of Fujian Province, China.The aim of this study was to identify the specific microorganisms and factors that significantly influence the treatment duration in patients suffering from severe infections.