Metal- and Reagent-Free Intramolecular Oxidative Amination of Tri- and Tetrasubstituted Alkenes

A metal-
and reagent-free, electrochemical intramolecular oxidative amination
reaction of tri- and tetrasubstituted alkenes has been developed.
The electrosynthetic method proceeds through radical cyclization to
form the key C–N bond, allowing a variety of hindered tri-
and tetrasubstituted olefins to participate in the amination reaction.
The result is the efficient synthesis of a host of alkene-bearing
cyclic carbamates and ureas and lactams.