Tdap maternal immunization and infant follow-up trials: Immunogenicity, transplacental transfer of pertussis antibodies, safety following pertussis immunization during pregnancy and its impact on infant pertussis immune response

This video supports the two published articles by KP Perrett, et al. Immunogenicity, transplacental transfer of pertussis antibodies and safety following pertussis immunization during pregnancy: Evidence from a randomized, placebo-controlled trial. Vaccine. 2020;38(8):2095-2104, and KP Perrett, et al. Impact of tetanus-diphtheria-acellular pertussis immunization during pregnancy on subsequent infant immunization seroresponses: follow-up from a large randomized placebo-controlled trial. Vaccine. 2020;38(8):2105-2114.

These articles describe the results of two clinical trials, respectively.
First study - a maternal immunization trial which assessed the safety and immunogenicity of a reduced antigen content diphtheria-tetanus-acellular pertussis (Tdap) vaccination during pregnancy, as well as the transfer of maternal pertussis antibodies through the umbilical cord.
Second study - an infant follow-up study which assessed the safety and immunogenicity of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus and Haemophilus influenza type B vaccine (DTPa-HBV-IPV/Hib) when administered to healthy infants born to mothers vaccinated in the maternal immunization trial.

本视频支持KP Perrett等发表的两篇已发表文章：《孕期接种破伤风白喉无细胞百日咳（Tdap）疫苗的安全性及免疫原性，以及母体破伤风抗体的经胎盘转移：来自一项随机、安慰剂对照试验的证据》（《Vaccine》. 2020;38(8):2095-2104）以及《孕期接种破伤风-白喉-无细胞百日咳-乙型肝炎灭活疫苗-脊髓灰质炎灭活疫苗-流感嗜血杆菌B型疫苗（DTPa-HBV-IPV/Hib）对后续婴儿免疫应答的影响：来自一项大型随机安慰剂对照试验的后续研究》（《Vaccine》. 2020;38(8):2105-2114）。这两篇文章分别描述了两项临床试验的结果。

首项研究——一项母亲免疫试验，旨在评估孕期接种降低抗原含量Tdap疫苗的安全性及免疫原性，以及母体破伤风抗体通过脐带的转移情况。

第二项研究——一项婴儿随访研究，旨在评估对在母亲免疫试验中接种疫苗的母亲所生的健康婴儿接种破伤风-白喉-无细胞百日咳-乙型肝炎灭活疫苗-脊髓灰质炎灭活疫苗-流感嗜血杆菌B型疫苗（DTPa-HBV-IPV/Hib）的安全性及免疫原性。