Forearm Bone Mineral Density of Normal Indian Population

Background and Objectives: Bone density measurements by dual-energy X-ray absorptiometry (DEXA) recognized now as a safe and accurate technique[1] is being done frequently. But the T- score and Z-score values are interpreted using the reference value of Asian population provided by the manufacturer and not of Indian population. This may lead to improper diagnosis of Osteoporosis in Indian population. In this context we compared the young reference values and age-related values of bone density of the normal Indian population with the reference value of Asian population provided by the manufacturer. Methods: Through DEXA normal healthy individuals who were prospective renal donors were scanned. Results & Conclusion: Bone Mineral Density (BMD) of distal radius and ulna, proximal radius and ulna, proximal radius of normal Indian female and BMD of proximal radius and ulna of male population are found to be less considering the reference value of Asian population provided by the manufacturer. Hence it may be inappropriate to use the reference value of Asian population provided by the manufacturer to calculate the T- score and Z-score in Indian population.

研究背景与目的：双能X线吸收法（dual-energy X-ray absorptiometry, DEXA）目前已被公认为一种安全且精准的骨密度检测技术[1]，临床应用日益广泛。但当前检测所得的T评分（T-score）与Z评分（Z-score）均采用厂商提供的亚洲人群参考值进行解读，而非适配印度人群的专属参考值，这可能导致印度人群骨质疏松症的诊断出现偏差。基于此背景，本研究将印度正常人群的骨密度年轻成人参考值与年龄相关参考值，与厂商提供的亚洲人群参考值展开对比分析。
研究方法：本研究通过双能X线吸收法对拟作为肾脏捐献者的健康正常个体进行扫描检测。
结果与结论：经对比发现，印度正常女性群体的桡骨远端及尺骨、桡骨近端及尺骨、桡骨近端的骨密度（Bone Mineral Density, BMD），以及印度男性群体的桡骨近端及尺骨骨密度，均显著低于厂商提供的亚洲人群参考值。因此，在印度人群中使用厂商提供的亚洲人群参考值计算T评分与Z评分，可能并不恰当。