RNA-seq on aortic valves from WT vs N1-haploinsufficient telomere-shortened (generation 2 Terc-/-) mice with either healthy AVs or AV stenosis treated with control solvent or XCT790 Overall design: RN
Circadian clocks are molecular timekeeping mechanisms that allow organisms to anticipate daily changes in their environment. The fundamental cellular basis of these clocks is delayed negative feedback
