RNAseq analysis of cocaine associated transcriptional dynamics in the thalami of Maged1 WT and cKO mice.

Maged1 inactivation induces insensitivity to cocaine by impairing cocaine-evoked release of dopamine and plasticity in the Nucleus accumbens (NAc). Here we have characterized the chromatin epigenetic and transcriptional alterations associated with chronic cocaine exposure in the paraventricular thalamus (PVT, one of the main regulatory inputs of the Nac) in mice WT or conditional KO for Maged1 activity. Overall design: We dissected the thalami of WT or Maged1 cKO mice after repeated (5) injections of cocaine or saline vehicle. At least 3 independent biological replicates were processed per each experimental condition.