Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity
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Fragment-based discovery of pyrazolopyridones as JAK1 inhibitors with excellent subtype selectivity Descriptor: (1~{S})-2,2-bis(fluoranyl)-~{N}-[4-(3-methyl-6-oxidanylidene-2,7-dihydropyrazolo[3,4-b]pyridin-4-yl)cyclohexyl]cyclopropane-1-carboxamide, Tyrosine-protein kinase JAK1 Authors: Hansen, B.B, Jepsen, T.H, Larsen, M, Sindet, R, Vifian, T, Burhardt, M.N, Larsen, J, Seitzberg, J.G, Carnerup, M.A, Jerre, A, Molck, C, Rai, S, Nasipireddy, V.R, Griessner, A, Ritzen, A. Deposit date: 2019-12-13 Release date: 2020-06-10 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Fragment-Based Discovery of Pyrazolopyridones as JAK1 Inhibitors with Excellent Subtype Selectivity. J.Med.Chem., 63, 2020
创建时间：
2019-12-13
