Cinchona Alkaloid Squaramide-Catalyzed Asymmetric Ugi-Type Reaction of Isocyanoacetates with C,N-Cyclic Azomethine Imines: Access to Chiral Oxazole-Substituted Tetrahydroisoquinolines
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https://figshare.com/articles/dataset/_i_Cinchona_i_Alkaloid_Squaramide-Catalyzed_Asymmetric_Ugi-Type_Reaction_of_Isocyanoacetates_with_C_N-Cyclic_Azomethine_Imines_Access_to_Chiral_Oxazole-Substituted_Tetrahydroisoquinolines/10039580
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We reported herein an unexpected cinchona alkaloid-derived squaramide-catalyzed asymmetric two-component Ugi-type reaction of α-aryl-substituted isocyanoacetates with C,N-cyclic azomethine imines, which provides concise access to optically active C1-oxazole-substituted tetrahydroisoquinolines in good yields (86–93%) and high enantioselectivities (up to 98% enantiomeric excess) under mild conditions.
创建时间：
2019-10-10
