Dysbiotic microbiome triggers Th17 cells to mediate oral mucosal immunopathology in mice and humans

Animal model implicates microbiota-triggered oral mucosal Th17 cells as drivers of local immunopathology and therapeutic targets in periodontitis. Total RNA from gingival tissues from mice undergoing experimental periodontitis . Each mouse has a ligated (induction site) side and a control side and mice are treated with an inhibitor of TH17 inflammation (GSK805 (RORγt Inverse Agonist II)) or vehicle control. We are interested in the differences in gingival inflammation in the presence/absence of the inhibitor. Mice have a strong response to treatment by clinical score.