Functional evaluation of the vestibular system of guinea pigs poisoned by an organophosphate through caloric stimulation

PURPOSE:this study aimed to assess the functioning of the vestibular system of guinea pigs exposed to the organophosphate chlorpyrifos, acutely, through caloric stimulation electronystagmography.METHODS:the research conducted an experimental electronystagmography of guinea pigs exposed to organophosphate for 10 consecutive days, at doses 0.5 mg / kg / day and 1.0 mg / kg / day intraperitoneally and compared with a control group that received distilled water administration. We performed caloric ice (10 º C) and compared the variables frequency of appearance of nystagmus in 10 seconds (u / s) and angular velocity of the slow component (º / s).Results:the results showed no statistically significant difference in the comparison of variables between groups.CONCLUSION:we conclude that the tested doses of the pesticide organophosphate chlorpyrifos caused no detectable functional damage in the caloric test.研究目的：本研究旨在通过温度刺激眼震电图（caloric stimulation electronystagmography），评估急性暴露于有机磷农药毒死蜱（chlorpyrifos）的豚鼠的前庭系统功能。 研究方法：本研究对连续10天以0.5 mg/kg/天、1.0 mg/kg/天的剂量腹腔注射该有机磷农药的豚鼠开展实验性眼震电图检测，并以给予蒸馏水注射的豚鼠作为对照组进行对比。本次检测采用10℃冰冷水进行温度刺激，对比分析两项观测变量：10秒内眼震出现频率（u/s）及眼震慢相角速度（°/s）。 研究结果：各组间各项观测变量的比较均未发现统计学显著性差异。 结论：综上可得出结论，本研究所测试的毒死蜱剂量未在温度刺激试验中造成可检测到的前庭功能损伤。