Senescence induced by BMI1 inhibition is a therapeutic vulnerability in H3K27M-mutant DIPG
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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We studied the effect of BMI1 inhibition in diffuse intrinsic pontine glioma cells (DIPG).We reported the application of chromatin immunoprecipitation sequencing for high-thoughput profiling of BMI1 and H2AK119ub in diffuse intrinsic pontine glioma cells (DIPG) in response to BMI1 inhibition.We also performed bulk RNA sequencing of DIPG cells in response to pharmacological inhibition or knockdown of BMI1.
我们研究了BMI1抑制在弥漫内生型桥脑胶质瘤（diffuse intrinsic pontine glioma, DIPG）细胞中的作用。我们报道了针对BMI1抑制处理的DIPG细胞，采用染色质免疫共沉淀测序对BMI1及组蛋白H2A赖氨酸119泛素化（H2AK119ub）进行高通量图谱分析的应用。此外，我们还对经药物抑制或基因敲低BMI1处理的DIPG细胞开展了批量RNA测序。
提供机构：
University of Colorado, Denver - Anschutz Medical Campus
创建时间：
2022-02-20
