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Miz-1 is required to coordinate the pre-TCR-dependent transitional step in DN3/DN4 thymocytes

ChEBI2011-08-23 更新2026-07-21 收录

胸腺细胞发育

pre-TCR信号通路

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-28342 数据链接链接失效反馈

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资源简介：

Miz-1 is required to coordinate the pre-TCR-dependent transitional step in DN3/DN4 thymocytes

应用场景：

创建时间：

2011-08-23

胸腺细胞发育

基因表达谱分析

Review on the role of Bcl11b in thymus and periphery and impact on diseases RNA was extracted from DP thymocytes of bcl11bf/fCd4cre/tcra-/- and tcra-/- mice. Tcra-/- mice only have preselected DP thym

NIAID Data Ecosystem80

Identification and Characterization of Thymus LIM Protein: Targeted Disruption Reduces Thymus Cellularity

胸腺细胞发育

基因功能验证

We have identified a novel LIM gene encoding the thymus LIM protein (TLP), expressed specifically in the thymus in a subset of cortical epithelial cells. TLP was identified as a gene product which is

PubMed Central40

Increased p300 Expression Inhibits Glucocorticoid Receptor-T-Cell Receptor Antagonism but Does Not Affect Thymocyte Positive Selection

胸腺细胞发育

细胞信号通路

Positive selection of T cells is postulated to be dependent on the counterinteraction between glucocorticoid receptor (GR)- and T-cell-receptor (TCR)-induced death signals. In this study we used T-cel

PubMed Central30

Development of Double-positive Thymocytes at Single-cell Resolution

胸腺细胞发育

单细胞免疫组学

We applied single-cell sequencing to mouse thymocytes and analyzed the transcriptome data using Seurat. By applying unsupervised clustering, we defined thymocyte subtypes and validated DP cell subtype

NIAID Data Ecosystem60

RNAseq of Notch signaling responsive and unresponsive thymus DN1a/b cells

Notch信号通路

胸腺细胞发育

We report the gene expression profile of thymus DN1a/b cells that are either responsive to Notch signals, or unresponsive to Notch signals due to absence of expression of RBPJ, a key mediator of the N

NIAID Data Ecosystem30

Miz-1 is required to coordinate the pre-TCR-dependent transitional step in DN3/DN4 thymocytes

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