Structure of the kinase domain of human DDR1 in complex with a potent and selective inhibitor of DDR1 and DDR2
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Structure of the kinase domain of human DDR1 in complex with a potent and selective inhibitor of DDR1 and DDR2 Descriptor: 1,2-ETHANEDIOL, 3-(2-imidazo[1,2-a]pyrazin-3-ylethynyl)-~{N}-[3-[(4-methylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl]-4-propan-2-yl-benzamide, Epithelial discoidin domain-containing receptor 1, ... Authors: Pinkas, D.M, Fox, A.E, Kupinska, K, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. Deposit date: 2018-06-25 Release date: 2018-08-08 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J. Med. Chem., 61, 2018
创建时间：
2018-06-25
