HLA-associations to anti-JCV antibody status in Scandinavian cohort.

Results from the association analysis between HLA-alleles and JCV seropositivity in the Scandinavian MS cases and the Swedish controls. The frequencies in the second column are the frequencies of HLA alleles among JCV Ab seropositive and seronegative respectively. In the crude analysis each allele was analysed on its own, adjusted for gender and age. The analysis was performed in in R version 2.15.1 [50]. The analysis was adjusted for age at sampling and gender. Age at sampling was divided into four categories, 18–29, 30–39, 40–49, and 50 and older, with group 40–49 as the reference. *Multivariate: all nominally significant alleles from the same gene in the same model, adjusted for age and gender.Common extended HLA haplotypes were selected from those published in the literature for the Caucasian population [19]–[21]. Alternative common DRB1*15 haplotypes DQB1*06:02-DQA1*01:02-DRB1*15-B*07-C*07-A*02, DQB1*06:02-DQA1*01:02-DRB1*15-B*07-C*07-A*03, DQB1*06:02-DQA1*01:02-DQB1*15-B*51-C*?-A*02, DQB1*06:02-DQA1*01:02-DRB1*15-B*51-C*?-A*11. The DQB1*03:01-DQA1*05-DRB1*11-B*51-A*02 haplotype exist with many different C alleles, C*05 not being the most common one.